Sol M Bobst, PhD DABT
About
Dr. Sol M. Bobst is a toxicologist with board certification in toxicology through the American Board of Toxicology. His work spans regulatory and computational toxicology, with particular focus on chemical risk assessment, mutagenicity and carcinogenicity prediction, and the toxicological evaluation of consumer products.
His published research, appearing in journals including Toxicological Sciences, Regulatory Toxicology and Pharmacology, and Chemosphere, reflects a range of interests across the field. His work includes in silico modeling approaches for predicting skin sensitization, mutagenicity, and carcinogenicity, as well as studies examining endocrine-disrupting chemicals and their interactions with nuclear hormone receptors. He has also published on the derivation of oral reference doses for specific compounds, cannabinoid product toxicology, and, earlier in his career, on the role of maternal autoantibodies in preeclampsia. This combination of computational and regulatory methodologies suggests experience applicable to chemical exposure assessment, product safety evaluation, and the interpretation of toxicological data in contested scientific contexts.
Publications
- ToxPoint: Toxicology Studies on Δ9-tetrahydrocannabinol and Cannabidiol-containing Products Available to Consumers Are Lacking.
- Skin sensitization in silico protocol.
- Integration of in silico methods and computational systems biology to explore endocrine-disrupting chemical binding with nuclear hormone receptors.
- Prediction of mutagenicity and carcinogenicity using in silico modelling: A case study of polychlorinated biphenyls.
- Oral Reference Dose for ethylene glycol based on oxalate crystal-induced renal tubule degeneration as the critical effect.
- Maternal autoantibodies from preeclamptic patients activate angiotensin receptors on human mesangial cells and induce interleukin-6 and plasminogen activator inhibitor-1 secretion.
- Maternal autoantibodies from preeclamptic patients activate angiotensin receptors on human trophoblast cells.
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