Lucy H Fraiser, PhD
About
Dr. Lucy H. Fraiser is a researcher with a background in pharmacology and toxicology, with published work concentrated on the mechanisms and clinical consequences of cyclophosphamide, a chemotherapy agent used in cancer treatment. Her research has examined the drug's metabolic activation, pharmacokinetics, and organ toxicity across murine models, with particular attention to bladder toxicity and lung injury. That work appeared in journals including Chemical Research in Toxicology, Toxicology and Applied Pharmacology, and Toxicology.
Her published record also includes work on prostate cancer treatment, specifically transperineal iodine-125 implantation and its five-year outcomes in terms of tumor control and morbidity, published in the International Journal of Radiation Oncology, Biology, Physics. Additional publications address environmental topics, including hazardous waste incineration, reflected in a contribution to Environmental Science and Technology.
With seven peer-reviewed publications spanning chemotherapy toxicology, radiation oncology outcomes, and environmental science, Dr. Fraiser's expertise spans both the laboratory characterization of drug-induced organ injury and the clinical and environmental dimensions of toxic exposure, areas that translate naturally to matters involving pharmaceutical toxicity, chemotherapy-related harm, and environmental health litigation.
Credentials
Publications
- Letters: About hazardous waste incineration.
- Transperineal 125iodine implantation for treatment of clinically localized prostate cancer: 5-year tumor control and morbidity.
- Acrolein mercapturates: synthesis, characterization, and assessment of their role in the bladder toxicity of cyclophosphamide.
- Murine strain differences in metabolism and bladder toxicity of cyclophosphamide.
- Pharmacokinetics, metabolic activation, and lung toxicity of cyclophosphamide in C57/B16 and ICR mice.
- Cyclophosphamide toxicity. Characterising and avoiding the problem.
- Apparent congenital anterior urethral stricture in brothers.
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