Michael Trousdale
About
Michael Trousdale is a researcher whose work centers on ocular immunology and the biology of the lacrimal gland. His published work, spanning more than 115 peer-reviewed articles, addresses the mechanisms underlying autoimmune conditions affecting the lacrimal and salivary glands, with particular attention to Sjögren's syndrome and related dacryoadenitis models.
His research has appeared in journals including Investigative Ophthalmology and Visual Science, Cornea, Current Eye Research, and the Scandinavian Journal of Immunology. Representative studies include investigations of autoimmune dacryoadenitis induced in rabbit models, gene transfer approaches using adeno-associated virus to suppress lacrimal gland immunopathology, changes in aquaporins and chloride channels in Sjögren's syndrome, and the role of lacrimal epithelial cell mediators in regulating dendritic cell phenotype and lymphocyte proliferation. One published study also examined the effect of weather on walking behavior in older adults, reflecting a broader engagement with aging-related research questions.
Publications
- Autoimmune dacryoadenitis and sialadenitis induced in rabbits by intravenous injection of autologous lymphocytes activated ex vivo against lacrimal antigens.
- The effect of weather on walking behavior in older adults.
- Changes of chloride channels in the lacrimal glands of a rabbit model of Sjögren syndrome.
- Changes of aquaporins in the lacrimal glands of a rabbit model of Sjögren's syndrome.
- Systematic variations in immune response-related gene transcript abundance suggest new questions about environmental influences on lacrimal gland immunoregulation.
- Distinct dacryoadenitides autoadoptively transferred to rabbits by different subpopulations of lymphocytes activated ex vivo.
- Adeno-associated virus-mediated IL-10 gene transfer suppresses lacrimal gland immunopathology in a rabbit model of autoimmune dacryoadenitis.
- Suppression of lymphocyte proliferation and regulation of dendritic cell phenotype by soluble mediators from rat lacrimal epithelial cells.
- Long-term topical cyclosporine treatment improves tear production and reduces keratoconjunctivitis in rabbits with induced autoimmune dacryoadenitis.
- Microporous poly(L-lactic acid) membranes fabricated by polyethylene glycol solvent-cast/particulate leaching technique.
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