Ronald Tjalkens
About
Ronald Tjalkens, Ph.D., is a neuroscientist and toxicologist whose research centers on how environmental exposures affect the nervous system and immune system, with particular focus on neuroinflammation, neurodegeneration, and the neuro-immune axis. His work examines how toxic exposures across the lifespan, including during developmental periods, contribute to conditions such as Parkinson's disease and other neurological disorders.
Tjalkens has published more than 90 peer-reviewed studies in journals including PLoS Pathogens, Toxicology, and Frontiers in Toxicology, among others. His research addresses mechanisms of microglial activation, NF-kB signaling in glial cells, and the role of environmental toxins in initiating or accelerating neurodegenerative processes. He has investigated the effects of manganese exposure during early development, alpha-synuclein pathology linked to environmental toxins, and potential neuroprotective compounds in preclinical models of Parkinson's disease. He holds an Investigator-Initiated Research Award from the Congressionally Directed Medical Research Programs to explore synthetic molecules relevant to Parkinson's disease, and he has received support from the National Institute of Environmental Health Sciences for his work on environmental contributors to neurological disease.
Credentials
Publications
- Exposure to manganese during juvenile development increases microglial activation in the hippocampus following systemic infection with A/California/04/2009 Influenza A H1N1 virus.
- Reflections on the NIEHS Virtual Consortium funding mechanism (ViCTER) and what it has taught us about the future of transdisciplinary science.
- Microglia-specific NF-κB signaling is a critical regulator of prion-induced glial inflammation and neuronal loss.
- Sex Specific Effects of Environmental Toxin-Derived Alpha Synuclein on Enteric Neuronal-Epithelial Interactions.
- Sex specific effects of environmental toxin-derived alpha synuclein on enteric neuronal-epithelial interactions.
- Discrimination of Jamaican fruit bat lymphocytes by flow cytometry.
- Neuroprotective efficacy of the glucocorticoid receptor modulator PT150 in the rotenone mouse model of Parkinson's disease.
- Neuroprotective Efficacy of the Glucocorticoid Receptor Modulator PT150 in the Rotenone Mouse Model of Parkinson's Disease.
- Comparative safety, pharmacokinetics, and off-target assessment of 1,1-bis(3'-indolyl)-1-(p-chlorophenyl) methane in mouse and dog: implications for therapeutic development.
- Bis-Indole Derivatives as Dual Nuclear Receptor 4A1 (NR4A1) and NR4A2 Ligands.
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