Robert B. Raffa, PhD
About
Robert B. Raffa is a pharmacologist and pain researcher affiliated with the College of Pharmacy at the University of Arizona Health Sciences and Temple University School of Pharmacy. His work centers on analgesic pharmacology, pain mechanisms, and opioid-related therapeutics, with particular attention to mixed-mechanism analgesics, postoperative respiratory depression, and the neuroscience of pain perception.
His publication record spans more than 380 peer-reviewed works in journals including the Journal of Pain Research, Cureus, and Frontiers in Medicine. Recent contributions include investigations into mathematical modeling of pain pathways using coupled feedback control systems, the concept of a regulatory "nocistat" for pain homeostasis, microbiome influences on nicotine withdrawal, and clinical considerations around lower-dose opioid formulations such as hydrocodone. He has also contributed to an e-Delphi study on defining and managing postoperative respiratory depression, reflecting engagement with both basic science and applied clinical questions.
In addition to his academic and research roles, Dr. Raffa is associated with Raffa Consulting Economists in Winter Park, Florida, indicating involvement in consulting activities that bridge pharmacological expertise with applied professional contexts.
Publications
- A Pain Memory "Trace": Cumulative Pain Perception and Damping During Fight-or-Flight Response Modeled with a Lotka-Volterra-Style Coupled Feedback Control Loop System.
- A Pilot Convenience Survey of Clinicians' Perception of the Desirability of a Lower Dose Option of an Opioid Analgesic: Hydrocodone as an Example.
- Defining, Evaluating, and Managing Postoperative Respiratory Depression: An e-Delphi Study.
- Mixed-mechanism analgesics for mixed pain.
- A Pluripotent Progression of the Gate Control System Theory of Pain - Modeling Ascending & Descending Pain Pathways as a Lotka-Volterra Coupled Control & Feedback Loop.
- Correction: Microbiome Alteration Prevents Abstinence-Induced Nicotine Withdrawal in a Well-Established Planarian Model.
- Microbiome Alteration Prevents Abstinence-Induced Nicotine Withdrawal in a Well-Established Planarian Model.
- Postulate of the Existence of a 'Nocistat': Rationale and Implications for Novel Analgesics.
- Mortality 30, 60, and 90 Days After Discharge Is Greater in Patients Who Experienced Postoperative Respiratory Depression and Pulmonary Complication.
- On the Principle and Value of Test Signaling ("Pinging") in Pain Pathways: A Part of an Overarching Principle in Psychophysical Phenomena?
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