Frank Johnson (System Engineering And Laboratories (SEAL))
About
Frank Johnson is a research scientist whose published work centers on vaccine development, with a particular focus on glycoconjugate vaccine platforms. His peer-reviewed contributions, appearing in journals including Vaccine, Vaccines, Carbohydrate Research, and PLoS One, address the immunogenicity and preclinical evaluation of conjugate vaccines targeting pathogens such as Group B Streptococcus, Haemophilus influenzae type a, Shigella, and Vibrio cholerae. This body of work spans the chemistry of polysaccharide conjugation, carrier protein selection, and GLP toxicology studies supporting vaccine advancement.
Additional published research includes a scoping review on hearing loss associated with congenital syphilis and a study on laparoscopic surgical training methodology, reflecting a broader engagement with clinical and public health topics. Across seven peer-reviewed publications, his work touches on both the laboratory science of vaccine design and translational questions relevant to immunization programs.
Publications
- All roads lead to Rome: N-acetylation of GBS Capsular Polysaccharides is linked to conjugate vaccine immunogenicity.
- Development of a Novel Shigella Quadrivalent Conjugate Vaccine Using Shigella O-Polysaccharide and IpaB Carrier Protein.
- Preclinical immunogenicity studies of Haemophilus influenzae type a glycoconjugate vaccine.
- Evaluation of Cholera Toxin B Subunit as a Novel Carrier Protein for Polysaccharide Conjugate Vaccines.
- Preclinical Immunogenicity of a 6-Valent GBS Glycoconjugate Vaccine from a Repeat-Dose GLP Toxicology Study.
- Scoping review of hearing loss attributed to congenital syphilis.
- Training of laparoscopic novices both individually and in dyads using a simulation task.
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